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Studies
by Gloria Gamat on September 9, 2006

Collectively refer to as autism spectrum disorders, autism and related conditions have become increasingly common, affecting 50 in every 10,000 children as compared with five in 10,000 two decades ago.
Autism, characterized by social and language abnormalities and repetitive patterns of behavior, may have increased in actual incidence and/or partially due to the higher levels of awareness these days and the improved diagnostic processes.
In previous studies, older parental age been associated to abnormalities in the children's brain development but few studies have effectively examined the effect of mothers' and especially fathers' ages on autism.
A research team headed by Abraham Reichenberg, Ph.D., of the Mount Sinai School of Medicine, New York, and Institute of Psychiatry, King's College London, evaluated this association in children born during the 1980s in Israel and found that older age among fathers was associated with increased risk of autism; an association that persisted even after controlling for year of birth, socioeconomic status and the mother's age.
The authors of the study concluded that the above study provides the first convincing evidence that advanced paternal age is a risk factor for autism spectrum disorder, even if further work is necessary to confirm such findings.
Find more details at King's College London News.
Permalink: Older Fathers = Autistic Children?
Trackback: http://publish.creative-weblogging.com/publish/mt-tb.pl/35846
Mr Wong
Vote for Older Fathers = Autistic Children?:
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Rating: 8.00 out of 3 vote(s) cast.
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Response from:
Leslie
(01/16/07 8:54pm)
The observation that autistic children had much older fathers and sometimes also older mothers had been made since the 1980s and even prior to that by Christopher Gillberg and others and in September of 2005 MB Lauritsen et. al. found that increasing paternal age and not maternal age was associated with autism. 943,664 children were followed for seven years in Denmark in this study. There have been eight large studies that found that increasing paternal age was linked to non familial schizophrenia. It is time that men and women be advised of the risks of fathering past 35. Of course when autism is already in the family there is a very high risk of autism in a particular child. One suggestion is men cryopreserving semen in their 20s for possible later fathering. There are many disease and conditions which increase in offspring of older fathers including cancers, Alzheimer's and over 30 major birth defects. Duchennes Muscular Dystrophy and Hemophilia increase with the age of the maternal grandfather. No child deserves to be born with autism or with the fate of developing schizophrenia. It has been shown that there is more DNA damage in sperm by 35 and apoptosis, the mechanism where sperm with defective DNA are killed, stops working around the age if 35.
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