Whole Network Most Recent TOP10 Diagnostics News Studies Treatment

 

Anti-TNFá Monoclonal Antibody, Infliximab: Reduced Exacerbations in Symptomatic Moderate Asthma

Filed in archive Studies , Treatment by Gloria Gamat on October 11, 2006

Anti-TNFá Monoclonal Antibody, Infliximab: Reduced Exacerbations in Symptomatic Moderate Asthma
In the first October 2006 issue of the American Journal of Respiratory and Critical Care Medicine (published by the American Thoracic Society), a reseach paper reported that treatment of anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody to patients with symptomatic moderate asthma resulted to fewer disease exacerbations compared to the placebo group.

Trevor T. Hansel, M.D., Ph.D., of the National Heart and Lung Institute at Royal Brompton Hospital in London with 11 other associates infused 14 patients with infliximab, a monoclonal antibody that binds and neutralizes tumor necrosis factor alpha (TNFá).

Infliximab popular brand name is Remicade(R).

According to Dr. Hansel:

"Anti-TNFá therapy has been shown to be effective in patients with rheumatoid arthritis, Ankylosing spondylitislinks, Crohn's disease and psoriasis, but ineffective in patients with chronic obstructive pulmonary disease (COPD).

Preliminary reports of efficacy in asthma patients with concomitant rheumatoid arthritis have been encouraging. Small prospective studies of a soluble receptor directed against TNFá in severe refractory asthma have also shown improvements in lung function and airway hyperresponsiveness."

"Treatment with infliximab reduced the number of moderate exacerbations in patients with asthma, as monitored by morning and evening use of an electronic spirometer incorporating a clinical diary. Although infliximab therapy did not show significant efficacy for the primary endpoint of monitoring peak expiratory flow (PEF), it did produce a significant decrease in the diurnal (during the day) variation in the PEF rate."


No adverse events associated with using the monoclonal antibody for treatment were reported, meriting anti-TNFá therapy further study in larger clinical trials in severe asthma patients.

Read more at Science Daily.

Photo Credit: [asthma.upmc.com]


Advertisement




Permalink: Anti-TNFá Monoclonal Antibody, Infliximab: Reduced Exacerbations in Symptomatic Moderate Asthma
Tags: antitumor  necrosis  factor  alpha  TNFa  infliximab  remicade  asthma  anti  monoclonal+antibody 

Trackback: http://www.creative-weblogging.com/cgi-bin/mt-tb.pl/38948



Advertisement


Advertisement


RSSrss   | See all blog subscribe options
Googlegoogle   |   What is RSS?
Yahoo!yahoo
AddthisAddThis Feed Button
BloglinesBloglines
Newsletter

Use our search feature to look for other interesting posts

Just this blog Whole network
 
  • Advertise with us

  • Learn more about our advertising options or email advertising - at - creative-weblogging.com or give Luis a call at +1 (650) 331 8047.


  • Testimonials

  • 'Thanks, for a very interesting and informative Blog.'

    'Thanks for doing this; it's a terrific site.'

    'I don't know...but why I don't find such informative and profitable blogs so often, I suspect blogging world is becoming so small that we can't find such lucrative blogs like this one.'
Health & Medicine - Top Blogs Philippines
  • Other blogs in the same channel in the Creative Weblogging Network







 
Tagcloud: Allergies Alzheimer's Disease Arthritis Bacteria and Bacterial Infections Blog Carnivals Bone Health Cancer Cardiovascular Health Cases Consumer Alert Controversies Diabetes Diagnostics Diarrhea Diet Dietary Supplements and Vitamins Digestive Disorders Epilepsy Eye Health FDA Approvals Functional Foods Genetics HIV & AIDS Influenza Investigational Kid's Health Lung Conditions Lupus Medical Blogs & Blogging Medical Career Medical Devices Men's Health Mental Maladies Miscellany Multiple Sclerosis Muscular Disorders Nanotechnology Neurological Disorders News Obesity Opinion Oral Health Pain Management Parkinson's Disease Plants & Herbs Poison & Antidotes Pregnancy & Child Birth Psoriasis & Skin Diseases Sexual Health Sleep Disorders Sponsored Post Studies Treatment Tuberculosis Viruses and Viral Infection Weight Loss Women's Health